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Computerised Interventions for Behaviour and Emotion Regulation lab

Thomas E. Gladwin

My research focuses on using neurostimulation and (online) computerized interventions such as cognitive bias modification to improve mental health. There are two broad approaches. First, to develop and critically test complementary computerised therapy forms that can target unconscious, involuntary processes involved in, e.g., anxiety or addiction. Second, to enhance brain activity and neuroplasticity related to reflectivity and control processes.

Fields of expertise include:

  • Cognitive neuroscience
    • Data analysis for fMRI, EEG (time and time-frequency domain) and peripheral signals
    • Neurostimulation via tDCS
  • Use and development of implicit measures
  • Cognitive Bias Modification for mental health issues
  • Online and lab-based task programming
  • Data analysis and statistical methods

Current projects and available participation opportunities 

  • Novel methods for implicit measures of automatic processes
  • Computerized interventions for addiction
  • Improving resilience and self-regulation via manipulation of emotional responses to threatening stimuli
  • Activating prefrontal cortex to enhance cognitive control and reduce cognitive decline in dementia

Research participants are always very welcome, both for ongoing studies and for helping to pilot studies in preparation. It may also be possible to help gather data or to develop and collaborate on a related project.

Some recent past projects

Testing effects of combined transcranial Direct Current Stimulation and Cognitive Bias Modification on relapse in alcohol addiction. With the University of Amsterdam. This provided preliminary evidence that prefrontal brain stimulation, possibly in particular when combined with training, can improve clinical outcomes.

Development and application of the Shooting Task to study threat-induced freezing and impulsivity. With Radboud University Nijmegen and the Donders Center for Cognitive Neuroimaging. A virtual shoot-or-be-shot task was developed that revealed how threat-induced freezing reflects action preparation under inhibitory constraints. This task was subsequently adapted to a stop-signal variant and used to study effects of sleep deprivation on self-control.

Aggression-related changes in brain activation after deployment. With the Dutch Ministry of Defence. In a number of fMRI studies, differences between veterans with and without anger disorders were tested. Effects involving the relationships between emotional versus control regions were found, on resting state connectivity and stimulus-evoked activation.

Any other member(s) involved including faculty, PhD students, research volunteers

  • Dr. Antonina Pereira
  • Matt Jewiss
  • Dr. Ian Tyndall
  • Shane McLoughlin

Recent publications

Van Peer JM, Gladwin TE, Nieuwenhuys A (2018). Effects of Threat and Sleep Deprivation on Action Tendencies and Response Inhibition. Emotion, in press.

Woud M, Zlomuzica A, Cwik J, Margraf J, Shkreli L, Blackwell S, Gladwin TE, Ehring T (2018). Effects of appraisal training on responses to recalling a distressing autobiographical event. Journal of Anxiety Disorders, in press.

Gladwin TE, Möbius M, McLoughlin S, Tyndall I (2018). Anticipatory versus Reactive Spatial Attentional Bias to Threat. British Journal of Psychology, doi: 10.1111/bjop.12309.

Boendermaker WJ, Gladwin TE, Peeters M, Prins PJM, Wiers RW (2018). Training Working Memory in Adolescents using Serious Game Elements. JMIR Research Protocols, in press.

Gladwin TE, Vink M (2018). Freeze or forget? Virtual attack effects in an emotional Sternberg task. Europe's Journal of Psychology, in press.

Gladwin TE, Vink M (2018). Alcohol-related Attentional Bias Variability and conflicting automatic associations. Journal of Experimental Psychopathology, in press.

Gladwin TE, Salemink E, Garritsen H, Noom S, Kraaij G, Wiers RW (2018). Is alcohol-related aggression related to automatic alcohol-power or alcohol-aggression associations? Psychology of Violence, 8(2), 229-237.

Varkevisser T, Gladwin TE, Heesink L, van Honk J, Geuze E (2017). Resting-state functional connectivity in combat veterans suffering from impulsive aggression. Social Cognitive and Affective Neuroscience, 12(12), 1881-1889.

Heesink L, Gladwin TE, Vink M, van Honk J, Kleber R, Geuze E (2017). Neural activity during the viewing of emotional pictures in veterans with pathological anger and aggression. European Psychiatry, 47, 1-8. doi: 10.1016/j.eurpsy.2017.09.002.

Heesink L, Gladwin TE, Terburg D, van Honk J, Kleber R, Geuze E (2017). Proximity alert! Distance related cuneus activation in military veterans with anger and aggression problems. Psychiatry Research: Neuroimaging, 266, 114-122, doi: 10.1016/j.pscychresns.2017.06.012.

Gladwin TE (2017). Carryover effects in spatial attentional bias tasks and their relationship to subclinical PTSD symptoms. Traumatology, 23(4), 303-308. doi: 10.1037/trm0000121.

Gladwin TE (2017). Negative effects of an alternating-bias training aimed at attentional flexibility: A single session study. Health Psychology and Behavioral Medicine, 1, 41-56, doi: 10.1080/21642850.2016.1266634.

Gladwin TE (2017). Attentional bias variability and cued attentional bias for alcohol stimuli. Addiction Research and Theory, 25 (1): 32-38, doi: 10.1080/16066359.2016.1196674.

Gladwin TE, Wiers CE, Wiers RW (2017). Interventions aimed at automatic processes in addiction: Considering necessary conditions for efficacy. Current Opinion in Behavioral Sciences, 13: 19-24. doi: 10.1016/j.cobeha.2016.08.001.

Den Uyl TE, Gladwin TE, Rinck M, Lindenmeyer J, Wiers RW (2016). A clinical trial with combined transcranial Direct Current Stimulation and alcohol approach bias retraining. Addiction Biology, 22(6), 1632-1640. doi: 10.1111/adb.12463.

Korucuoglu O, Gladwin TE, Baas F, Mocking RJT, Ruhe HG, Groot PFC, Wiers RW (2016). Neural response to alcohol taste cues in youth: effects of the OPRM1 gene. Addiction Biology, doi: 10.1111/adb.12440.

Wiers CE, Gladwin TE, Ludwig VU, Gropper S, Stuke H, Wiers RW, Walter H, Bermpohl F (2016). Comparing three cognitive biases for alcohol cues in alcohol dependence. Alcohol and Alcoholism, doi: 10.1093/alcalc/agw063.

Den Uyl TE, Gladwin TE, Wiers RW (2016). Electrophysiological and behavioural effects of combined transcranial Direct Current Stimulation and alcohol approach bias retraining in hazardous drinkers. Alcoholism: Clinical and Experimental Research, 40(10), 2124-2133, doi: 10.1111/acer.13171.

Woud M, Salemink E, Gladwin TE, Wiers RW, Becker E, Lindenmeyer J, Rinck M (2016). Alcohol homograph priming in alcohol-dependent inpatients. Sucht, 62, 217-224, DOI: 10.1024/0939-5911/a000432.

Gladwin TE, Vink M, Mars RB (2016). A landscape-based cluster analysis using recursive search instead of a threshold parameter. MethodsX, 3: 477-482, doi: 10.1016/j.mex.2016.06.002.

Gladwin TE, Hashemi MM, van Ast V, Roelofs K (2016). Ready and waiting: Freezing as active action preparation under threat. Neuroscience Letters, 619, 182-188, doi:10.1016/j.neulet.2016.03.027.

Ly V, Bergmann TO, Gladwin TE, Volman I, Usberti N, Cools R, Roelofs K (2016). Reduced affective biasing of instrumental action with tDCS over the prefrontal cortex. Brain Stimulation, S1935-861X(16)30004-3, doi: 10.1016/j.brs.2016.02.002.

Wiers CE, Shumay E, Cabrera E, Shokri-Kojori E, Gladwin TE, Skarda E, Cunningham SI, Kim SW, Wong CTC, Tomasi D, Wang G-J, Volkow ND (2016). Reduced sleep duration mediates decreases in striatal D2/D3 receptor availability in cocaine abusers. Translational Psychiatry, 6, e752, doi:10.1038/tp.2016.14.

Korucuoglu O, Gladwin TE, Wiers RW (2016). The effect of acute alcohol on motor-related EEG asymmetries during preparation of approach or avoid alcohol responses. Biological Psychology, 114: 81-92.

Mars RB, Verhagen L, Gladwin TE, Neubert F-X, Sallet J, Rushworth MFS (2016). Comparing brains by matching connectivity profiles. Neuroscience & Biobehavioral Reviews, 60: 90-97.

Wiers RW, Gladwin TE (2016). Reflective and impulsive processes in addiction and the role of motivation. Reflective and Impulsive Determinants of Human Behavior, Eds Deutsch R, Gawronski B, Hofmann W. New York, NY: Psychology Press.

Gladwin TE, Wiers CE, Wiers RW (2016). Cognitive neuroscience of cognitive retraining for addiction medicine: From mediating mechanisms to questions of efficacy. In Hamed Ekhtiari, Martin Paulus, editors: Neuroscience for Addiction Medicine: From Prevention to Rehabilitation - Methods and Interventions, Vol 224, PBR, UK: Elsevier, 323-344.

Lojowska M, Gladwin TE, Hermans EJ, Roelofs K (2015). Freezing promotes perception of coarse visual features. Journal of Experimental Psychology: General, 144(6): 1080-1088, doi: 10.1037/xge0000117.

Wiers RW, Boelema S, Nikolaou K, Gladwin TE (2015). On the development of implicit and control processes in relation to substance use in adolescence. Current Addiction Reports, 2: 141-155, doi: 10.1007/s40429-015-0053-z.

Korucuoglu O, Gladwin TE, Wiers RW (2015). Alcohol-induced changes in conflict monitoring and error detection as predictors of alcohol use in late adolescence. Neuropsychopharmacology, 40(3):614-21, doi: 10.1038/npp.2014.209.

Wiers CE, Ludwig VU, Gladwin TE, ..., Walter H, Bermpohl F (2015). Effects of cognitive bias modification training on neural signatures of alcohol approach tendencies in male alcohol-dependent patients. Addiction Biology, doi: 10.1111/adb.12221.

Den Uyl TE, Gladwin TE, Wiers RW (2015). Transcranial Direct Current Stimulation, implicit alcohol associations and craving. Biological Psychology, 105: 37-42.

Vink M, Zandbelt BB, Gladwin T, Hillegers M, Hoogendam JM, van den Wildenberg WP, Du Plessis S, Kahn RS (2014). Frontostriatal activity and connectivity increase during proactive inhibition across adolescence and early adulthood. Hum Brain Mapp 35(9):4415-27, doi: 10.1002/hbm.22483.

Wiers CE, Stelzel C, Gladwin TE, ..., Walter H, Bermpohl F (2014). Effects of Cognitive Bias Modification-training on neural alcohol cue reactivity in alcohol-dependence. The American Journal of Psychiatry, 172(4), 335-343,

Gladwin TE, Mohr SE, Wiers RW (2014). The potential role of temporal dynamics in approach biases: Delay-dependence of a general approach bias in an alcohol Approach-Avoidance Task. Frontiers, doi: 10.3389/fpsyg.2014.01398.

Gladwin TE, Rinck M, Eberl C, Becker ES, Lindenmeyer J, Wiers RW (2014). Mediation of Cognitive Bias Modification for alcohol addiction via stimulus-specific alcohol avoidance association. Alcoholism: Clinical and Experimental Research, 39 (1): 101-107.

Van Hecke J, Gladwin TE, Coremans J, Hulstijn W, Sabbe B (2014). Functionele MRI bij schizofrenie: belang van aangepaste taak in de scanner. Tijdschrift voor Psychiatrie, 56 (6): 385 - 393.

Gladwin TE, Figner B (2014). "Hot" cognition and dual systems: Introduction, criticisms, and ways forward. In: Frontiers of Cognitive Psychology Series: Neuroeconomics, Judgment and Decision Making, Eds Wilhelms E, Reyna VF. New York: Psychological Press, 157-180.